Research Group "Cell Polarity and Cancer"

Cell polarization is crucial for development and tissue homeostasis, and aberrant polarity contributes to various diseases. The Iden laboratory investigates functions of polarity proteins in

  • skin morphogenesis and homeostasis
  • epithelial regeneration and stress responses
  • intercellular communication
  • coupling of mechanical and biochemical signals
  • different types of cancer

We investigate how deregulated polarity signaling impacts on cyto-architecture, survival and cell death in vivo using genetically modified mice in developmental and disease models as well as 2D and 3D in vitro cell culture systems. Our aim is to better understand how cell polarity affects age-associated pathologies to reveal novel directions for targeted therapies.


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Iden Lab News

Orchestration of tissue-scale mechanics and fate decisions by polarity signalling

new review article coming out soon

Postdoc position available in our lab in Homburg!

Interested to join our recently relocated team to work on exciting questions in mammalian tissue homeostasis? See details here

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EMBO LTF for Martim - congratulations!

We are very happy for Martim Dias Gomes, who was awarded an EMBO Long-Term Fellowship for his next adventures in the lab of Guillaume Charras at UCL! Proud of you & wishing you lots of success!

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Dr. Carvalho Fernandes Dias Gomes!

Martim passed his PhD thesis exam with distinction. Big congrats & well deserved!! (PhD #7)

Dr. Knapp!

Sina delivered a great virtual PhD defense on her pigment cell research - very well done & congratulations, Dr. Knapp! (PhD #6)

New preprint

Sina's work just out: Polarity proteins promote skin pigmentation through melanin synthesis pathway. Check out in bioRxiv:

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