Cell polarization is crucial for development and tissue homeostasis, and aberrant polarity contributes to various diseases. The Iden laboratory investigates functions of polarity proteins in
We investigate how deregulated polarity signaling impacts on cyto-architecture, survival and cell death in vivo using genetically modified mice in developmental and disease models as well as 2D and 3D in vitro cell culture systems. Our aim is to better understand how cell polarity affects age-associated pathologies to reveal novel directions for targeted therapies.
