CECAD Microsite



  • Dias Gomes M*, Letzian S*, Saynisch M, and Iden S. Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity. Nature Communications 10, 3362 (2019) (*: co-first authors) https://rdcu.be/bMftV

  • Vorhagen S*, Kleefisch D*, Persa OD, Graband A, Schwickert A, Saynisch M, Leitges M, Niessen CM#, and Iden S#. Shared and independent functions of aPKClambda and Par3 in skin tumorigenesis. Oncogene, (*: co-first authors; #: shared corresponding authors) https://www.nature.com/articles/s41388-018-0313-1#Sec1
  • Mescher M*, Jeong P*, Knapp SK, Rübsam M, Saynisch M, Kranen M, Landsberg J, Schlaak M, Mauch C, Tüting T, Niessen CM, and Iden S. The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma. The Journal of Experimental Medicine, (*: co-first authors) http://jem.rupress.org/content/214/2/339
  • Rahn E, Thier K, Petermann P, Rübsam M, Staeheli P, Iden S, Niessen CM, Knebel-Mörsdorf, D. Epithelial barriers in murine skin during Herpes simplex virus 1 infection: the role of tight junction formation. The Journal of Investigative Dermatology, 2017 Apr;137(4):884-893. doi: 10.1016/j.jid.2016.11.027. Epub 2016 Dec 6
  • Ding X, Bloch W, Iden S, Rüegg MA, Hall MN, Leptin M, Partridge L, Eming SA. mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nature Communications 2016 Oct 27; doi: 10.1038/ncomms13226
  • Ali NJA, Dias Gomes M, Bauer R, Brodesser S, Niemann C, and Iden S. Essential role of polarity protein Par3 for epidermal homeostasis through regulation of barrier function, keratinocyte differentiation and stem cell maintenance. The Journal of Investigative Dermatology 2016 Dec;136(12):2406-2416. doi: 10.1016/j.jid.2016.07.011. Epub 2016 Jul 21.
  • Tuncay H, Brinkmann BF, Steinbacher T, Schürmann A, Gerke V, Iden S, Ebnet K. JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Nature Communications 2015 6:8128 doi: 10.1038/ncomms9128

  • Schlereth SL, Iden S, Mescher M, Ksander BR, Bosch JJ, Cursiefen C, Heindl LM. A Novel Model of Metastatic Conjunctival Melanoma in Immune-Competent Mice. Invest Ophthalmol Vis Sci. 2015 Sep;56(10):5965-73. doi: 10.1167/iovs.15-17290.
  • Refaian N, Schlereth SL, Koch KR, Notara M, Hos D, Mescher M, Iden S, Bosch JJ, Jager MJ, Cursiefen C, Heindl LM. Comparing the Hem- and Lymphangiogenic Profile of Conjunctival and Uveal Melanoma Cell Lines. Invest Ophthalmol Vis Sci. 2015 Aug 1;56(9):5691-5697. doi: 10.1167/iovs.15-16829.
  • Mescher M, Iden S. Par Proteins in Tumor Formation and Progression. Cell Polarity 2. Role in Development and Disease. Springer 2015, VIII. ISBN 978-3-319-144466-5. Book Chapter
  • Mescher M, Iden S. Function of Mammalian Cell Polarity Regulators in Skin Cancer. Cell News (DGZ) 2014/04
  • Schlereth S, Refaian N, Iden S, Cursiefen C, Heindl LM. Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis. BioMed Research International. 2014:639058. Epub 2014 Sep 1
  • Iden S*, van Riel WE, Schäfer R, Song J-Y, Hirose T, Ohno S, Collard JG. Tumor Type-Dependent Function of the Par3 Polarity Protein in Skin Tumorigenesis. Cancer Cell 2012 Sep;22(3):389-403. (*: corresponding author)
  • Iden S, Misselwitz S, Peddibhotla SSD, Tuncay H, Rehder D, Gerke V, Robenek H, Suzuki A, Ebnet K. aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation. The Journal of Cell Biology 2012 Mar;196(5):623-39.
  • Ellenbroek SIJ, Iden S, Collard JG. Cell polarity proteins and cancer. Seminars in Cancer Biology 2012 Mar;22(3):208-215.
  • Ellenbroek SIJ, Iden S, Collard JG. The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network. Small GTPases 2012;3(1):4-14.
  • Niessen MT, Iden S, Niessen CM. The in vivo function of mammalian cell and tissue polarity regulators - how to shape and maintain the epidermal barrier. Journal of Cell Science 2012 2012;125(Pt 15), 3501-3510
  • Semler O, Garbes L, Keupp K, Swan D, Zimmermann K, Becker J, Iden S, Wirth B, Eysel P, Koerber F, Schoenau E, Bohlander SK, Wollnik B, Netzer C. A Mutation in the 5′-UTR of IFITM5 Creates an In-Frame Start Codon and Causes Autosomal-Dominant Osteogenesis Imperfecta Type V with Hyperplastic Callus. The American Journal of Human Genetics 2012 Aug 10;91(2):349-57
  • Ebnet K, Gerke V and  Iden S. Cadherins and the regulation of tight junctions and cell polarity. Molecular and Functional Diversities of Cadherin and Protocadherin, 2010. ISBN 9788130803951. Book chapter
  • Iden S, Collard JG. Crosstalk between small GTPases and polarity proteins in cell polarization. Nature Reviews Molecular Cell Biology 2008 Nov;9(11):846-59
  • Ebnet K, Iden S, Gerke V, Suzuki A. Regulation of epithelial and endothelial junctions by PAR proteins. Frontiers in Bioscience. 2008;13:6520-36
  • Pardo J, Wallich R, Ebnet K, Iden S, Zentgraf H, Martin P, Ekiciler A, Prins A, Müllbacher A, Huber M, Simon MM. Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin. Cell Death and Differentiation 2007 Oct;14(10):1768-79.
  • Mandicourt G, Iden S, Ebnet K, Aurrand-Lions M, Imhof B a. JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration. The Journal of Biological Chemistry 2007 Jan;282(3):1830-7
  • Iden S, Rehder D, August B, Suzuki A, Wolburg-Buchholz K, Wolburg H, Ohno S, Behrens J, Vestweber D, Ebnet K. A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. EMBO reports 2006 Dec;7(12):1239-46.
  • Rehder D, Iden S, Nasdala I, Wegener J, Brickwedde M-KMZ, Vestweber D, Ebnet K. Junctional adhesion molecule-a participates in the formation of apico-basal polarity through different domains. Experimental Cell Research 2006 Oct;312(17):3389-403.
  • Heuer H, Maier MK, Iden S, Mittag J, Friesema ECH, Visser TJ, Bauer K. The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone-sensitive neuron populations. Endocrinology 2005 Apr;146(4):1701-6
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