CECAD Microsite

Research Group "Cell Polarity and Cancer"

Overview

Cell polarization is crucial for development and tissue homeostasis, and aberrant polarity contributes to various diseases. The Iden laboratory investigates functions of polarity proteins in

  • skin morphogenesis and homeostasis
  • epithelial regeneration and stress responses
  • intercellular communication
  • coupling of mechanical and biochemical signals
  • different types of cancer

We investigate how deregulated polarity signaling impacts on cyto-architecture, survival and cell death in vivo using genetically modified mice in developmental and disease models as well as 2D and 3D in vitro cell culture systems. Our aim is to better understand how cell polarity affects age-associated pathologies to reveal novel directions for targeted therapies.

 

 

Iden Lab News

Dr. Letzian, congratulations!

Soriba successfully defended his PhD thesis on his work of polarity proteins in epidermal genome integrity - cheers!


EMBO Workshop "Cell Polarity and Membrane Dynamics" 2019

Pete Cullen and Sandra are excited to organize the next EMBO Workshop on above topic at beautiful Sant Feliu de Guixols in May 2019 - stay tuned!


new paper - Genetic interaction of aPKClambda and Par3 in skin cancer

Our joint paper with our neighbours Carien Niessen & team just came out - Congrats, Dominik, Susi and everybody involved - this was a marathon!


seeking student assistant

interested? see "open positions"


International meeting of the DFG SPP1782 in July

“Epithelial intercellular junctions as dynamic hubs to integrate forces, signals and cell behavior”

Read more

new lab member

Pegah Seddigh joined our lab as new postdoc - welcome!!


new lab member

Annika Graband joined us as new PhD student - welcome!!


Dr. Ali!

Congratulations to a successful PhD defense, Noelle!