CECAD Microsite

Research Group "Cell Polarity and Cancer"


Cell polarization is crucial for development and tissue homeostasis, and aberrant polarity contributes to various diseases. The research group of Sandra Iden investigates functions of polarity proteins in

  • skin morphogenesis and homeostasis
  • epithelial regeneration and stress responses
  • intercellular communication
  • different types of cancer

We investigate how deregulated polarity signaling impacts cyto-architecture, survival and cell death using genetically modified mice in developmental and disease models as well as 2D and 3D in vitro cell culture systems. Our aim is to better understand how cell polarity affects age-associated pathologies to reveal novel directions for targeted therapies.

Iden Lab News

new lab member

Pegah Seddigh joined our lab as new postdoc - welcome!!

new lab member

Annika Graband joined us as new PhD student - welcome!!

Dr. Ali!

Congratulations to a successful PhD defense, Noelle!

new paper: polarity proteins as extrinsic suppressors of melanoma

The lab's new paper in JEM reveals that polarity proteins dictate cell shape and function of neighbouring tissue-resident cells. Epidermal Par3...

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new paper!

Congratulations to Noelle for her paper accepted in JID! Thanks again also to all co-authors - Cheers

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Master thesis project available

A Master thesis project is available for a highly motivated life science student interested in exploring mechanisms driving mammalian epithelial cell...

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and again ... PhD defense

our new lab member "Dr. Kleefisch" - congrats to a successful defense, Dominik!

PhD defense

Melina successfully defended her PhD thesis in April - congratulations, Melina!